胆石症例を中心とした肝・胆道系,腎臓および膵臓の相関性についての臨床病理学的並びに病理形態学的研究

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概要

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• We studied the relationship of the liver-bile duct system and kidneys and pancreas with 22 patints by the laboratory data and histopathological appearances. The patients had cholelithiasis, acalculous cholecystitis or gastroduodenal disease and were not complicated by malignant tumor, hepatic cirrhosis and severe systemic disease had not begun on hemodialysis.<BR>Then, they were selected from the patients routinely examined during the past twenty years in the 1st department of pathology of the medicine, Showa university. The following are the results of the above studies:<BR>1) Comparing the obstructive jaundice group with that of the non-obstructive jaundice, especially in the former we recognized a close relationship of the liver-bile duct system and kidneys and pancreas.<BR>2) In the obstructive jaundice group, comparing the oparated patients for bile duct disease-cholelithiasis -with the non-operated patients, there was no difference between the two.<BR>3) In the non-obstructive jaundice group, comparing the operated patients for up-perabdominal disease, except bile duct disease, with the non-operated patients, there was a little closer relation of the three organs in the former than in the latter.<BR>4) Comparing the gall-stone group with the non-gallstone group, there was a closer relation of the three organs, especially in the gallstone group with obstructive jaundice.<BR>5) On histopathological study, there were icteric change and fatty degeneration and slight fibrous degeneration in the liver, and cloudy swelling and necrobiosis and precipitation of the bile pigment of the renal tubules in the kidneys, and acute necrotic inflammatory changes and slight fibrosis in the pancreas.<BR>6) On the laboratory data, there were increased alkaline phosphatase, blood urea nitrogen (BUN), serum amylase and elevation of bilirubin.<BR>As stated above, we recognized significant correlation of the liver-bile duct system and kidneys and pancreas, especially severe in the patients of obstructive jaundice, studying mainly patients of cholelithiasis.

• 学校法人 昭和大学・昭和医学会の論文

著者

• 新田 増雄

  昭和大学医学部第一病理学教室

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