Hydroxyethyl starchが血液ガス酸塩基平衡,及び循環動態に及ぼす影響について

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概要

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• By promtly giving an intravenous injection of 10 ml/kg of H.E.S. to a dog of normovolemia, the auther cross-examined change of blood gas, acid-base balance and circulatory movement. The effect obtained were as follows:<BR>1. The rise of Po<SUB>2</SUB> after the H.E.S. injection was so little, as compared with that in clinical examples, that it was not considered to be satistically much significant.<BR>2. Notwithstanding the insignificant change of Paco<SUB>2</SUB>, after the H.E.S. injection, PHa went down significantly, base dificit increased, and metabolic acidosis was found generated.<BR>3. From the viewpoint of falling down of hemoglobin concentration, it seemed that the effect of plasma expander would be preserved at least for 60 minites.<BR>4. After the H.E.S. injection, it was recognized that cardiac output considerably increased, arterio-venous oxygen content conspicously decreased, and accordingly, oxygen consumption diminished remarkably, suggesting some trouble on oxygen utilization in tissues.<BR>It was supposed that this, together with the diluted acidosis, would be one of the reasons of the abovestated metabolic acidosis.<BR>5. With the H.E.S. injection, blood was diluted, hemoglobin concentration was weakened, and hence arterio-venous oxygen content was decreased, but according to the exceeding increase of cardiac output, oxygen availabilty was rather increased.<BR>6. After the H.E.S. injection, physiologycal shunt was increased, but it was not much increase as compared with that of cardiac output.<BR>7. After the H.E.S. injection, a tendency of A-aDo<SUB>2</SUB> decrease was shown, but the change was not much significant.<BR>8. With the H.E.S. injection, mean arterial blood pressure was not changed, but cardiac output was increased and peripheral resistance was decreased.

• 学校法人 昭和大学・昭和医学会の論文

著者

• 松崎 史朗

  昭和大学医学部麻酔学教室

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• Hydroxyethyl starchが血液ガス酸塩基平衡,及び循環動態に及ぼす影響について

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