ダンピング症候群の発生機序に関する実験的研究--主として微小循環からの考察
スポンサーリンク
概要
- 論文の詳細を見る
The author observed the micro-circulatory behavior in stomach, intestines and abdominal walls during experimental dumping for the purpose of elucidating its mechanism of onset. The method consisted in examining micro-circulatory changes in these organs of mouse or adult rat weighting about 100 grams, under the influence of dumping induced by injection of 2 ml of 50% glucose solution into upper jejunum.<BR>As a result, the blood flow became slow in a few minutes after the injection, accompanying stasis, sluding of blood cells, regurgitation, etc., and such changes reached to the maximum in 10 to 15 minutes, returned to normal in about 50 minutes. And contraction of intestinal villi and stasis of villous blood flow were also observed immediatery after dropping of 50% glucose solution directly on jejunal mucosa, and blood flow began to recover gradulally in a few minutes, returned completely to normal in about 50 minutes.<BR>Based on the idea that such changes may be due to a vasoactive substance, the author intended to examin micro-circulatory changes by dropping solutions of serotonin, his-tamin, epinephrin and bradykinin, while observing the capillary circulation in serous surface of intestinal wall of rat. The result is that serotonin showed similar changes to the micro-circulatory changes which was observed in case of the experimental dumping, accompaying the sludge phenomenon.<BR>On the presumption that serotonin have an effect upon such micro-circulatory changes, it was examined, eventual liberation of sorotonin was studied by a fluoro-histochemical method on serotonin-containing cells within jejunal wall. The result was that in jejunal mucosa, 15 minutes after injection of 50% glucose, there was a remarkable reduction in serotonin-fluorescence, which was obsered in abundance before, and that even 15 minutes after, there was no such reduction in those mucosa which had not come in contact with the glucose solution injected.<BR>From the experiments, the author conclude that early dumping syndrome might be caused by a general disturbance of the capillary circulation, associated with local insufficiency due to the osmotic pressure and subsequent liberation of serotonin, after the intake of high osmotic meal into upper jejunum.