Flurazepam free faseの使用経験--Nitrazepamとの比較検討

概要

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Thirty-two out-patients of our department who came with a complaint of sleeping disturbance (16 males and 16 females), were given with 10-20 mg of flurazepam free base, and 16 patients among them were given further 5-10 mg of nitrazepam in turn before going to bed. The following results were obtained. 1. Among 32 cases received with flurazepam free base, the drug was very effective in 6 cases, moderately effective in 16 cases, effective in 9 cases, and ineffective in 1 case ; among 16 cases received with the drug and nitrazepam in turn, flurazepam free base was more effective in 7 cases and was almost equally effective in 7 cases, and nitrazepam was more effective in 2 cases. 2. The actvities to induce sleeping and fast sleeping and to keep it were almost equal between these two drugs ; it may be said as the characteristic of flurazepam free base that it gave refreshing feeling when waking up and was free from hangover of the drug. However, in some cases, nitrazepam was more effective, and it will be further studied, which drug must be used in individual cases. 3. The used dose of flurazepam free base was 10-20 mg, and when increasing it, some complained unpleasantness on waking up. Usually a dose of 10-15 mg will give good sleeping. 4. No noteworthy side effect was observed in the biochemical test, complete blood count and urinalysis performed on 13 cases receiving flurazepam free base before and after the treatment.