Ceruloplasminの鉄代謝に及ぼす影響

概要

論文の詳細を見る
In iron deficiency anemia, there is a positive correlation between the rate in hemoglobin by the treatment with iron preparations and serum ceruloplasmin level. The effects of ceruloplasmin on iron metabolism were investigeted using copper deficient rats. In copperdeficient rats, the serum ceruloplasmin level was markedly decreased, and the release into the plasma of the 59FeSO4 infused into the stomach or peritoneal cavity was impaired. The transfer of the radioactive iron from the plasma to the liver was markedly increased. The radioactivity in the small intestine was determined at given stages following the infusion of 59FeSO4 into the stomach, and it was revealed that the radioactivity was high in copper-deficient rats. The release of the radioactive iton the serous membrane into the plasma was markedly impaired, and the transfer of the iron from the mucous membrane to the serous membrane was decreased. In the ceruloplasmin-free plasma, the binding of iron with transf errin was inhibited. From the results of the above-mentioned experiments, it was thought that ceruloplasmin would be related to the release of iron into the plasma through the binding of iron with transferrin by means of oxidizing Fe.