Nivalineの抗Cholinesterase作用

概要

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Nivaline is an alkaloid extracted from Galanthus nivalis L. and chemically, the same as Galanthamine. Nivaline showed potent anti-cholinesterase activity and used for a remedy of the treatment of myoparalysis clinically, such cases as poliomyelitis and myasthenia gravis etc. We have studied the relationship between the anti-cholinesterase activity and the effect of Nivaline as a remedy of the treatment of poliomyelitis. The following results were obtained. 1) Cholinesterase (ChE) activity in blood of patients suffering from acute anterior poliomyelitis following the administration of 0.25 mg, 0.5mg and 2.5mg of Nivaline is almost the same as the control. 2) In vitro, 10-4-10-5 M of Nivaline inhibited 50% of the specific and non-specific ChE activity. 3) ChE activity in brain and in liver of rat and mouse following the administration of Nivaline is almost the same as the control.
学校法人昭和大学・昭和医学会の論文