抗ヒスタミン剤の端板電位に及ぼす影響

概要

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Effects of several antihistaminics such as promethazine, triplennamine and pandryl-p, on the end-plate potential and action potential comparing with that of d-tubocurarine and decamethonium were studied electrophysiologically using sciatic-sartorius preparation of toads and phrenic-diaphragm preparation of rats by the Ozawa's insulation method. The following results were obtained :<BR>1) When Sciatic-sartorius preparation of toads were used, by the administration of the antihistaminics the action potential decreased gradually and finally disappeared completely and thereafter the end plate potential appeared markedly which were the same as the case of d-tubocurarine and decamethonium.<BR>2) When the phrenic-diaphragm preparation of rat was used, by the administration of d-tubocurarine almost the same effects were observed as the previous experiment, while by the administration of decamethonium, the latent period was prolonged remakably and the action potential did not disappeared which was followed to the end-plate potential.<BR>3) In case of promethazine and pandryl-p almost the same effects were observed as the case of decamethonium.
学校法人昭和大学・昭和医学会の論文