S-Benzoylthiamine O-Monophosphateの薬理-1-

スポンサーリンク

概要

• 論文の詳細を見る

• A pharmacological investigation was made on S-benzoylthiamine O-monophosphate (BTMP) and stated in the following are the results obtained thereof.<BR>Mice received and intravenous injection of BTMP in a dose of 2, 000 mg/kg showed acute intoxication and its LD<SUB>50</SUB> was found to be 2, 450 mg/kg. Namely, its toxicity is quite low.<BR>Likewise vitamin B<SUB>1</SUB>, there is a temporary lowering of the blood pressure in the rabbits received BTMP, but the elevation of the blood pressure which follows the injection of vitamin B<SUB>1</SUB> does not occur in the case of BTMP. Administration of BTMP increases the amplitude of cardiacc pulse, dilates coronary vessels and promotes respiration. BTMP causes contraction of the ear vessels of the rabbit, while the hind leg blood vessels of the toad dilate when the concentration is low and contract when the concentration is high.<BR>BTMP enhances the hypertensive effect of adrenaline on the rabbit, but it antagonizes the contractive effect of adrenaline on the hind leg vessels of the toad. And, moreover, it shows no influence on the effect of acetylcholine:<BR>BTMP promotes the motility of the smooth muscle organs (extirpated intestine and uterus of the rabbit) .

• 学校法人 昭和大学・昭和医学会の論文

著者

• 高橋 正宏

  太田綜合病院付属熱海病院

• 木下 誠

  昭和医科大学薬理学教室

• 山崎 雅治

  太田綜合病院

• 小森山 忠

  昭和医科大学薬理学教室

• 小沢 麻男

  昭和医科大学薬理学教室

• 富田 義純

  昭和医科大学薬理学教室

• 内田 長

  昭和医科大学薬理学教室

• 高橋 正宏

  太田綜合病院

関連論文

• 11.脳卒中後片麻痺の合併症に関する研究(4) : 廃用性筋萎縮 : 特に筋持久力低下と経時的変化について(脳卒中)
• 鶏胎仔におけるTheophyllineおよびTheobromineの体内分布について
• Thiamin tetrahydrofurfuryl disulfideの薬理-2-
• S-Benzoylthiamine O-Monophosphateの薬理-1-
• 水銀利尿剤「Salyrgan」ならびにGlutathioneの鶏胎仔におよぼす影響
• Thiamine Propyldisulfide(TPD)負荷による唾液中VitaminB1の消長について
• Cocarboxylaseに関する研究
• Reserpineの鶏胎仔に及ぼす影響,特に抗甲状腺作用について
• A case of pancreatic encephalopathy

スポンサーリンク