胃・大腸癌に対する抗癌剤感受性試験(CD-DST法)の臨床的検討

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Since August 2006 we have applied an <I>in vitro</I> chemosesitivity test using a collagen gel droplet embedded in a culture drug sensitivity test (CD-DST) to conduct individual chemosensitivity for each gastric and colorectal cancers. CD-DST was performed among 11 gastric cancer patients (19 samples) and 17 colorectal cancer patients (21 samples) in order to examine the characteristics of the patients and the results of the test. We exhibit the clinical course of4 patients with peritonitis carcinomatosa (2 with gastric cancer and 2 with colorectal cancer) . The evaluation of CD-DST succeeded at rates of 60.0% of the surgical specimens, 75% of ascites for gastric cancer cases: and 69.2% of the surgical specimens, 100% of ascites for colorectal cancer cases. The reasons for the failure of the CD-DST were lack of tumor cells in 3 cases of 4 surgical specimens, lack of tumor cells in one case, and poor proliferation of tumor cells in one of 2 samples of ascitic fluid in the gastric cancer cases. For the colorectal cancer cases, the reason for failure was contamination in all of 4 cases of surgical specimens. The sensitivity rates in 8 gastric cancer patients were 50.0% to 5-FU, 42.9% to CDDP, 57.1% to PTX, and 42.9% to SN-38: these in 12 colorectal cancer patients were 33.3% to 5-FU, 90.9% to L-OHP, 16.7% to SN-38, and 57.1% to PTX. Ac-cording to evaluation of treatments in 4 cases of peritonitis carcinomatosa with gastric and colorectal cancer, the changes of chemosensitivity to the drugs was recognized in comparison with its first sensitivity. The results suggest that repeated CD-DST using ascites might be clinically effective. CD-DST might be useful for individual cancer chemotherapy.
学校法人昭和大学・昭和医学会の論文

胃・大腸癌に対する抗癌剤感受性試験(CD-DST法)の臨床的検討

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