灌腸に関する研究
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概要
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Administering various calcium preparations (Ca-chloride, Ca-salicylate or Ca-sulfate) in combination with various narcotics (chloral hydrate, urethane or phenobarbital), which are considered to be well absorbed even when given as single enema, or magnesium sulfate, which is considered to be not easily absorbed, the author attempted to ovserve the influence of the above substances on the absorption of calcium in the colon in comparison with the results of the experiments by Mochizuki, in which, preliminary treatment was given with the subcutaneous injection of various narcotics. In addition, the author conducted experiments on the influence of histamine on the calcium absorption in the colon when histamine was given as enema in combination with these calcium preparations.<BR>As the results, the following conclusions were drawn:<BR>1) In the case of single enema of chloral hydrate, the rabbits demonstrated evident narcotized symptoms, but almost no changes were recognized in their serum calcium content. Roughly the same tendency was observed in the cases of urethane or of phenobarbital. In the case of single enema of magnesium sulfate, mild diarrhea was observed but almost no change was recognized in the serum calcium content as was in the former cases.<BR>2) Among these narcotics combined with calcium preparations given as enema, the absorption promoting action of chloral hydrate was most remarkable.<BR>3) Chloral hydrate promoted the absorption of calcium salicylate in the colon as well as the absorption of calcium chloride. Its promoting action on the absorption of calcium sulfate was slight.<BR>4) Urethane acted promotingly on the absorption of calcium chloride, but it did almot not promote the absorption of calcium salicylate or of calcium sulfate.<BR>5) Phenobarbital promoted the absorption of calcium chloride and calcium salicylate.<BR>6) Magnesium sulfate promoted only the absorption of calcium chloride.<BR>7) At the temperature of 18°-28°C, histamine (50 mg/kg given as single enema) was almost not absorbed from the colon. At the temperature of 30°C or more, histamine was absorbed.<BR>8) Histamine promoted the absorption of calcium preparations in the colon not as well as the above narcotics did, i. e., it sometime promoted and sometime did not at all.<BR>9) On the contrary, the absorption of histamine was promoted by calcium preparations, demonstrating intoxication symptoms.<BR>10) when the retention of the enema solution in the colon was roentgenographically examined, it was found that the enema solution is retained up to approximately 35 cm below the beginning of the ascending colon.
- 昭和大学・昭和医学会の論文