腫瘍細胞の細胞周期と放射線感受性について
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概要
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Cell cycle dependency was to be analysed more in detail especially that of G-1 phase because of the vital importance of this phase in preparing DNA precursors including TMP synthesis, metabolism around which has been suggested radio-sensitive in our laboratory. Double labelin method, H-TdR, and C-TdR was used in this experiment, which was expected the cell to mark the cycle more in detail.<BR>As the result, <BR>1. Irradiation did not influence the cell of S-phase in taking-up thymidine.<BR>2. Cells in S-phase including from early S to late S were more radio-resistant than in the other phase, G-2, M. and G-1, taken together.<BR>3. However, the cells in early S phase proved high radiosensitivity contrary to the entire S phase marked in single thymidine labeling.<BR>These findings were worth while in giving some proof upon the assumption that the metabolism around TMP Synthesis was too much disturbed by irradiation the cell to survive.
- 学校法人 昭和大学・昭和医学会の論文