ビタミンB2と脂質代謝に関する実験的研究-2-
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Studies were performed on the effect of fat metabolism on a relapse of Vitamin B<SUB>2</SUB> deficiency disease, and effectiveness of various kinds of Vitamin B<SUB>2</SUB> preparation against such relapsed conditions.<BR>Results were obtained as follows :<BR>1) Symptoms of Vitamin B2 deficiency could be detected much earlier in the group of rat with relapsed Vitamin B<SUB>2</SUB> deficiency disease as compared with those of incipient B<SUB>2</SUB> deficiency disease.<BR>Also gain in weight and recovery from symptom of B<SUB>2</SUB> deficiency after administrating Vitamin B<SUB>2</SUB> preparation were observed to be delayed in former group.<BR>2) Total amount of Vitamin B<SUB>2</SUB> in whole blood showed 4.5γ/dl (ester type, 3.5γg/dl) on the average on the first day of study in the convalescent stage.<BR>However, the average level of Vitamin B2 increased to 6.7γ/dl (ester type 5.7γ/dl) 25 days later, which revealed less lower than the average of 7.2γ/dl (ester type 6.4γ/dl) measured in the convalescent phase of the first experiment reported before. In case of dead specimen, total amount Vitamin B<SUB>2</SUB> contained in whole blood showed average of 3.5γ/dl (ester type 2.5γ/dl) .<BR>3) After diet for relapse of Vitamin B<SUB>2</SUB> deficiency food was given, the increasing rate of lipid in serum was much larger as compared with that of the first experiment which reported before.<BR>Especially, the group of rats fed by food which contained high amount of fat showed extremely higher level in serum lipid than those of groups which fed by medium and low amount of fat contained.<BR>Significant difference of variation in amount of lipid in sera among these three groups, however, was not observed.<BR>4) When Vitamin B<SUB>2</SUB> preparation was given to the rats with relapsed Vitamin B<SUB>2</SUB> deficiency disease, the delayed recovery from clinical aspects and improvement of fat metabolism were seen. Some of the rats died without showing any reactions even Free B<SUB>2</SUB> daily or B<SUB>2</SUB>-Butylate every four days.<BR>As the conclusion, daily dispense of B<SUB>2</SUB>-Butylate for B<SUB>2</SUB> dificiency disease is believed to be an excellent prescription.<BR>5) When symptom of B<SUB>2</SUB> deficiency disease relapses, it tends to get worse very quickly and a high degree of B<SUB>2</SUB> deficiency can be observed.<BR>Thus, if the B<SUB>2</SUB> preparation is not given at a proper time, it will be longer be effective and complete recovery could not be expected when B<SUB>2</SUB> preparation is dispensed after tissues have already changed.