セルロプラスミンに関する研究特に末梢赤血球へのFe59導入率を中心として

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Experiment were carried out bared on the consideration that ceruloplasmin was closely connected with synthesis of hemoglobin and deposit iron was mobilized by presence of ceruloplasmin. Fe59 incorporation into peripheral erythrocytes was investigated in the hungry rats injected with ceruloplasmin, folic acid and coenzym form of folic acid which was active type in the living body. The results obtained were as follows. 1) The ceruloplasmin did not induce acceleration of Fe59 incorporation rate into peripheral erythrocytes. But the combined use of ceruloplasmin and tetrahydro folic acid or N5-methyl THFA induced acceleration of its rate. 2) Ceruloplasmin was decomposed with 1 % trypsin into several polypeptide which had one hundred thousands, fifty thousands and less than ten thousands molecular weight respectively. The polypeptide of fifty thousands molecular weight induced promotion of rate of Fe59 uptake. 3) The human rerum resulted in appearance of accelerating substance of Fe59 incorporation into erythrocytes when incubated with light mitochondria isolated from kidney extracts of rats under exposition to hypoxic condition. The ceruloplasmin solution treated with the light mitochondria also induced acceleration of Fe59incorporation into erythrocytes. 4) The erythrocuprein did not induce promotion of Fe59 uptake.
学校法人昭和大学・昭和医学会の論文