Tetrahydrofolic acidの放射線防禦効果について
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概要
- 論文の詳細を見る
It was expected that radiation damages might be protected by THFA which was a precousor of folic acid and a easy oxydizable substance.<BR>These experiments were carried out to find the protective effect of THFA on both yeast cells and mice.<BR>As a results, it was found in yeast cells that THFA (10<SUP>-5</SUP>M) was effective in pretreatment but ineffective in post-treatment. There was no correlation between the protective effect and a labelled THFA concentration per cell.<BR>On the other hand, the number of mice surviving after 30 days increased significantly even in past-treatment, in which THFA (0.5mg) was injected intraperitoneally at 6 h. or 24 h. after irradiation. (500R or 750R)<BR>From these findings, it was supposed that THFA would effect as a reductive agents in yeast cells and as a promoter to the recovery of bone marrow cells resulting the decrease of bone marrow death in mice.
- 学校法人 昭和大学・昭和医学会の論文