切除胃よりみた随伴性胃炎の病理組織学的研究 特に病巣辺縁との比較検討
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概要
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The inflammatory changes in both the gastric mucosa and the mucosa surrounding ulcer, cancer and polyp were investigated histo-pathologically. Materials were obtained from 145 cases consisting of 71 cases of gastric ulcer, 53 cases of gastric cancer and 21 cases of gastric polyp. Based on the studies of the inflammatory changes in the gastric mucosa mede by Dr. Hirafuku et. al, the following classification and results were obtained:<BR>1. From three elements of P.F.I., the histological patterns of the attendant gastritis were divided into two patterns of non-metaplasia and metaplasia. They were classified into 18 patterns as follows:<BR>As non-metaplasical pattern ……8 patterns inclusive of normal.<BR>As metaplasical pattern …………4 patterns of diff usable metaplasia.<BR>6 patterns of antrum metaplasia.<BR>2. The antrum atrophic-hyperplastic gastritis (P<SUB>1</SUB>, P<SUB>1</SUB>×P<SUB>2</SUB>, P<SUB>1</SUB>I<SUB>2</SUB>, P<SUB>1</SUB>×P<SUB>2</SUB>I<SUB>2</SUB>) was most seen in the attendant gastritis of gastric ulcer. Accordingly, it was found mainly either in the non-metaplasical pattesn or the antrum metaplasical pattern.<BR>3. The mucosa surrounding ulcer was stronger in atrophy than the mucosa of gastric ulcer and higher at the attendant rate of intestinal metaplasia. Therefore, it can be said that the attendant gastritis of gastric ulcer is a ulcer-centric gastritis.<BR>4. The diff usable atrophic-hyperplastic gastritis (P<SUB>1</SUB>F<SUB>1</SUB>, P<SUB>1</SUB>×P<SUB>2</SUB>F<SUB>1</SUB>, (P<SUB>1</SUB>F<SUB>1</SUB>) I<SUB>2</SUB>, (P<SUB>1</SUB>×P<SUB>2</SUB>F<SUB>1</SUB>) I<SUB>2</SUB>, P<SUB>1</SUB>I<SUB>2</SUB>F<SUB>1</SUB>, P<SUB>1</SUB>×P<SUB>2</SUB>I<SUB>2</SUB>F<SUB>1</SUB>) and the antrum atrophic gastritis (P<SUB>2</SUB>, (P<SUB>2</SUB>F<SUB>1</SUB>) I<SUB>2</SUB>, P<SUB>2</SUB>I<SUB>2</SUB>) were many found in the attendant gastritis of gastric cancer which were many in order of the pattern each of the non-metaplasia, antrum metaplasia and diffusable metaplasia.<BR>5. The attendant gastritis of gastric cancer showed a stronger atrophy than that of gastric ulcer.<BR>6. The mucosa surrounding cancer was more atrophic-hyperplastic in comparison with the mucosa of gastric cancer. That is, it was liable to be weak in the extent of atrophy contrariwise to the gastric ulcer and this trend was especially remarkable in young people. Besides, high atrophy on the mucosa surrounding cancer was liable to be found in highlyaged people.<BR>7. The attendant gastritis of gastric polyp was seen in either pattern of the non-metaplasia or the antrum metaplasia and it was mainly found in those, the non-metaplasical (P<SUB>1</SUB>F<SUB>1</SUB>, P<SUB>1</SUB>×P<SUB>2</SUB>F<SUB>1</SUB>) and the antrum metaplasical pattern (P<SUB>1</SUB>I<SUB>2</SUB>F<SUB>1</SUB>, P<SUB>1</SUB>×P<SUB>2</SUB>I<SUB>2</SUB>F<SUB>1</SUB>), of the duff usable atrophic-hyperplastic gastritis.<BR>8. In the viewpoint that the atrophic-hyperplastic was found much in the mucosa of gastric polyp and that all the cases of the polyp surrounding particularly showed the atrophic-hyperplastic, it can be said that this atrophic-hyperplastic is one of the factors forming the polyp.<BR>9. Above all, "état mammelonné"was seen at a high rate in the mucosa of gastric polyp and the mucosa surrounding polyp. Furthermore, the gastric polyp as well as the"état mammelonné"was also seen in highly-aged people. For these facts, it is considered that this"état mammelonné"is one of the factors forming the polyp and it can, therefore, be said that the polyp is found many at the antrum.
- 昭和大学・昭和医学会の論文