鼻アレルギ-患者鼻粘膜誘発反応の日内変動

概要

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The nasal provocation test was performed for 7 patients with nasal allergy positive to skin test of H. D. and mite by measuring the threshold level with H. D. in the right nasal cavity and with mite in the left nasal cavity three times —10a.m., 3p.m. and 10p.m.— on the same day.The provocation test was performed by the disk method using a Disk manufactured by Torii Co. Ltd. which had a concentration (n. p.) of:H. D.: 5ug 25μg 125μg 600μgMite: 0.5ug 2.5ug 12.5ug 60.0ugThirteen (92.9%) of the total number of 14 patients with both H. D. and mite experienced a provocation with the lowest concentration in the morning, and (one case in the afternoon), while two such occurrences were noted in the evening with the same concentration as was given in the morning.In conclusion, in no patient was there a lower provocation threshold level in the afternoon and evening than in the morning and in most cases, provocation occurred with the lowest concentration in the morning.
耳鼻咽喉科臨床学会の論文