細菌内毒素による内耳障害 (山本馨教授退官記念論文集)

概要

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Repeated injections of endotoxin lipopolysaccharide from E. coli to mice at certain intervals induced the following changes in the inner ear.In the organ of Corti the inner and outer hair cells in the lower turn had degenerated and disappeared. The nerve fibers in the osseous spiral laminae partially disappeared in a part of the lower turn.In the stria vascularis, enlargement of the intercellular spaces, development of lysosomes in the cells, and degeneration were detected.The vestibular organ was accompanied by various degrees of degeneration and partial disappearance at the crista ampullares and at the sensory cells of type I and II constructing the maculae and the crista ampullares.The dark cells were also accompanied by increased vacuoles varying in size and by enlargement of the intercellular spaces, suggesting that the composition of the endolymph had changed.In the light of these results, Shwartzman reaction is suspected to be an additional cause of inner ear deafness or of vestibular disturbance.
耳鼻咽喉科臨床学会の論文