モルモットにおける脳波聴性誘発反応 (山本馨教授退官記念論文集)

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In the present study, the effects of exposure to high intensity noise arid ototoxic medication on hearing were investigated using the vertex provocative reaction, one of the objective hearing tests.Guinea pigs were exposed to high intensity pure tone, 2000 or 4000Hz, 110-120dBSPL, for 10 minutes or 1.5 hours. Nitromin and Furosemide were used for ototoxic medication.(1) Immediately after exposure to pure tone of high intensity, the threshold of reaction was elevated and the amplitude returned to a pre-exposure level later.(2) Intravenous injection of nitromin was followed by a similar increase in amplitude. A marked reduction in amplitude to a premedication level was observed 2 days after the administration of nitromin.(3) Following the administration of Furosemide there was a rapid decrease in amplitude with its subsequent gradual recovery. This phenomenon was considered to be due to changes in the stria vascularis.Changes in the function of hearing that occurred in an incipient stage of inner ear damage when no morphological changes were as yet demonstrable were thus studied in terms of EEG otological provocative reaction.
耳鼻咽喉科臨床学会の論文