放射線照射の喉頭粘膜表面微細構造に及ぼす影響に関する臨床的ならびに実験的研究 (三吉康郎教授開講20周年記念論文集)

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The fine surface structure of the laryngeal mucosa of humans and rats was investigated by using a scanning electron microscope and an X-ray microanalyser.Experimental materials were obtained from human patients who were treated with doses of 3000r to 4000r for laryngeal cancer and rats which had been raised on a normal diet or a diet deprived of vitamin E. These rats were experimentally irradiated with doses of 1000r to 1500r.Significant changes on the laryngeal surface of the humans were seen on the supraglottic areas and ventricular cavity which were composed of nonciliated cells. There was loss of nonciliated cells from the surface and tightly packed microvilli on the surface. In some areas of the ciliated laryngeal epithelium, there were compound cilia, blebformation, polyp-like formation of cilia, and/or shortened cilia.The surface structure of the larynges of the rats experimentally irradiated rat with doses of 1000r to 1500r showed similar findings to those of the humans. They were especially prominent in the vitamin E-defficient rats.The surface structure of laryngeal cancer treated with radiation showed a bulging formation of cells, an irregular surface of intercellular space.In the biochemical study using an X-ray microanalyser, phosphorus and sulfur were found more frequently on the laryngeal cancer than on the intact larynx.
耳鼻咽喉科臨床学会の論文