耳鼻咽喉科領域感染症に対するCefmetazoleについての臨床的研究

概要

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A new antibiotic cefmetazole (CMZ) was administered intravenously to 50 patients with acute otolaryngological infectious diseases, and its clinical effect was discussed. These were comprised 2 cases of middle ear infectious diseases, 1 case of acute sinusitis, 8 cases of peritonsillar abscesses, 26 cases of acute lacunar tonsillitis, 3 cases of acute sialoadenitis, 4 cases of oral infectious diseases and 6 cases of acute epiglottitis.Side effects of CMZ were noted in 2 cases. Skin rash was observed in 1 patient, besides serum transaminase was elevated in another.The clinical results were excellent in 28 cases, fair in 3 cases, while drug was discontinued in 3 cases, because of skin rash in one patient or diagnosed later as infectious mononucleosis in 2 patients. Of the 47 cases, the clinical effectiveness of CMZ was shown in 44 (93.6%).Bacteriological examination revealed gram-positive cocci in 24 cases, gram-negative bacilli in 9 cases and anaerobes in 5 cases. The MIC of CMZ was superior to that of CFX, CER or CEZ in case of gram-negative bacilli.
耳鼻咽喉科臨床学会の論文