内外リンパ混合による前庭半規管障害に関する実験的研究 (前庭機能異常の研究-2-<特集>)

概要

論文の詳細を見る
As a mechanism of the attack of Meniere's disease, membrane breake theory is proposed. The detailed observation of the effects induced by the mixture of endolymph with perilymph was considered to be useful for the diagnosis and treatment of vertiginous disease. We ruptured the saccular membrane of the guinea pig and observed the effects functionally and morphologically.Functionally, horizontal-rotatory-mixing spontaneous nystagmus to the healthy side was observed, however, behavioral observation evealed no deviating tendency.Morphologically, the degenerations of the sensori-epithelium, which were resemble to that induced by drug intoxication or accerating stimulus, were found in the maculae and the cristae ampullares. There were only slight disorders at the organ of Corti. Many vacuoles and vesicles and partial swelling were observed in the marginal cells, these findings were resemble to that of the dark cells and transitional cells of the cristae ampullares.By these results, discussions were made on the relationship among the range of degeneration, endolymphatic flow and the attack of Meniere's disease.
耳鼻咽喉科臨床学会の論文