副鼻腔炎とロキシスロマイシン少量長期投与

概要

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Seventeen adult patients with chronic sinusitis, who had been operated on or received conservative therapy for a long time but still complained of nasal symptoms, were treated with 150mg roxithromycin (RXM) per day for 6 months or more.1) Significant improvement both in nasal symptoms and in rhinoscopic findings was noted after 6 months, little improvement after 1 month of therapy.2) Great subjective improvement in nasal obstruction was noted, and volume and quality of nasal discharge showed objective improvement.3) No significant side effects were noted in any of the patients during this therapy.4) Long-term, low-dose RXM therapy was effective even when RXM-resistant bacteria were present. Therefore, this effect was not considered to be associated with its antibacterial activity but with some as not yet unknown mechanism.
耳鼻咽喉科臨床学会の論文