So-Called Carcinosarcoma in the Hypopharynx and Esophagus.

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So-called carcinosarcoma in the hypopharynx and cervical esophagus is a rare malignant neoplasm consisting of a squamous cell carcinoma and a sarcomatous appearing stroma. In this paper we describe two patients with this tumor; one in the hypopharyngeal posterior wall and one in the hypopharyngeal-esophageal anterior wall. The patients were a 41-year-old male who complained of pharyngeal pain and a 70-year-old female who complained of dysphagia. Histopathological and immunohistochemical examinations revealed spindle cell carcinoma in both cases. In the first, radiation therapy with 24 Gy was not effective, so radical resection and modified bilateral neck dissection were performed. Four months after the operation, a metastasis appeared in the parapharyngeal space. Chemotherapy with carboplatin (CBDCA) and fluorouracil (5-FU) and radiation therapy with 60 Gy were performed, but without effect. The patient died one year after the operation. In the second case, surgical therapy as in the first case was performed initially, and two courses of chemotherapy with cisplatin (CDDP) and peplomycin (PEP) were administered. The patient has had no recurrent tumors and no metastases during the 8 months since treatment.There have been only 8 reports of so-called carcinosarcoma in the hypopharynx in Japan. These 8 cases, plus our 2 cases, are reviewed.
耳鼻咽喉科臨床学会の論文