Usefulness of Ofloxacin Otic Solution.

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The clinical efficacy of ofloxacin otic solution was evaluated in acute purulent otitis media, exacerbation of chronic purulent otitis media, chronic purulent otitis media, otitis externa and myringitis. Two to ten drops of 0.3% ofloxacin otic solution were administrated once or twice a day for 7 days.1) The rate of clinical efficacy (excellent and good responses) judged by the doctor in charge was 75.9% (44/58), and judged by the peer review committee it was 61.5% (16/26).2) The rate of bacteriological elimination was 93.1% (27/29).3) The efficacy rate was higher in patients with chronic purulent otitis media treated twice a day (84.4% (27/32)) than in those treated once a day (65.4% (17/26)) (P<0.1), but no siginificant difference was observed between the two administration methods in patients with other diseases.4) In the patients with a history of operation, the rate of clinical efficacy was 83.3% (10/12), similar to that in those without a history of operation (73.8% (31/42)).5) None of the 71 patients examined had any side effects.6) It was concluded that ofloxacin otic solution is useful.
耳鼻咽喉科臨床学会の論文