Primary lymphomas of the nasal cavity and paranasal sinuses; A clinico-pathological study of 16 cases.

概要

論文の詳細を見る
Sixteen patients with extranodal lymphoma originating in the nasal and/or paranasal cavity were initially treated between 1975 and 1988 and have been followed for more than 12 months. In 11 patients the lymphoma was stage I, in 4 stage II and in one stage III. The majority were classified pathologically as T-cell types (81.2%) and high-grade lymphomas (68.8%) according to the Working Formulation. Three patients were treated with radiotherapy alone, and 8 received a combination of chemotherapy (VEMP or VEPA) and radiation. Two others were treated with chemotherapy alone. Local control by the initial treatment was fairly good. Eleven patients achieved a complete response (69%). The other 5 patients had high grade lymphomas with T-cell surface markers and showed a poor response. The 3-year survival rate of 9 patients with the tumor confined to the nasal cavity was 75%. The other 7 patients had involvement of the paranasal sinuses and failed to survive for 3 years. The overall 3-year survival rate was 45%. The ralatively low survival rate may be due to poor control of distant metastases. Better results might be achieved by more intense initial chemotherapy, such as MACOP-B or CHOP-B.