Transport mechanism in scala tympani and scala vestibuli. Benzylpenicillin concentration in perilymph.:-Benzylpenicillin Concentration in Perilymph-

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The concentrations of benzylpenicillin (penicillin G; PG) in sequential samples from the scala tympani (ST), scala vestibule (SV), cerebrospinal fluid (CSF) and serum of guinea pigs after the intravenous injection of 200mg/kg PG were measured by highperformance liquid chromatography. We also investigated PG concentrations in the perilymph of guinea pigs pretreated with the competitive organic anion transport inhibitor, probenecid (PR).We found a pronounced difference in the clearance curve of PG between ST and SV. Two hundred mg/kg of PR significantly increased the half-life time of PG in the serum, and also increased the PG concentration in the CSF. Pretreatment with the same dosage of PR inhibited the accumulation of PG in the ST and abolished the peaking of PG. This curve was very similar to that in the SV. PG concentrations in the SV were unaffected by pretreatment with PR. These data are analogous to the results of the furosemide experiments reported by Hara et al (1987).Our data suggest a difference in the anion transport mechanism between ST and SV.
耳鼻咽喉科臨床学会の論文