The combination therapy (tranilast and alterative treatment) in nasal allergy.

概要

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Sixteen patients with perennial nasal allergy were treated with tranilast combined with histamine γ-globulin conjugate for more than 4 weeks. Improvement was observed in 75% of the patients for sneezing, 71.4% for nasal discharge, 80% for nasal obstruction, 73.3% for swelling of the inferior turbinate, and 80% for the amount of nasal discharge.The global utility of this combination therapy was rated as "moderate to marked effectiveness" in 56.3% and as "slight to marked effectiveness" in 81.3%. Marked improvement of subjective symptoms was observed with this combination therapy, as compared with the tranilast treatment alone. Stomatitis was noted in 1 case but not severe enough to require discontinuation of the medication.It was thus concluded that this combination therapy is useful for treatment of perennial nasal allergy.
耳鼻咽喉科臨床学会の論文