Therapeutic effects of (2"R)-4'-O-tetrahydropyranyladriamycin on squamous cell carcinoma of the head and neck (phase II study).

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概要

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• (2''R)-4'-0-tetrahydropyranyladriamycin (THP) is a new anthracycline anticancer agent. THP has a tumoricidal effect stronger than or similar to Adriamycin, but weaker cardiotoxic and skin-damaging effects.THP was administered to 20 patients with head and neck squamous cell carcinoma. Sixteen patients (group A) received a dose of 20 mg for 3-5 consecutive days, and 4 patients (group B) received a dose of 30-40 mg every other day. Two patients showed complete response, and 7 patients showed partial response, the efficacy rate being 45%. There was no difference in the efficacy rate between groups A and B, but the 2 patients who showed complete response were in group B.THP was effective against head and neck squamous cell carcinoma.

• 耳鼻咽喉科臨床学会の論文

著者

• 古阪 徹

  駿河台日本大学病院耳鼻咽喉科

• 木田 亮紀

  駿河台日本大学病院耳鼻咽喉科

• 小泉 紋禎

  駿河台日本大学病院耳鼻咽喉科

• 横出 裕

  駿河台日本大学病院耳鼻咽喉科

• 川村 繁

  駿河台日本大学病院耳鼻咽喉科

• 飯塚 直樹

  駿河台日本大学病院耳鼻咽喉科

• 穴澤 卯恭

  駿河台日本大学病院耳鼻咽喉科

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• Therapeutic effects of (2"R)-4'-O-tetrahydropyranyladriamycin on squamous cell carcinoma of the head and neck (phase II study).
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