Morphological study of Newcastle disease virus infection in chicken nose.

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Newcastle disease virus infection following intranasal inoculation of chicks with a mesogenic strain of the virus produced a localized infection of the middle turbinate which was histologically demonstrable 3 days after inoculation. There was destruction of mucous cells of individual acini in the inner surface of the middle turbinate, and the infection spread rapidly to ciliated and goblet cells and to neighboring acini.By day 3, there was undulation or disappearance of the cilia and lymhoid cell infiltraion under epithelium. On day 5 the inflammation in the infected middle turbinate was more severe than on day 3, but by day 7 light microscopy showed almost complete recovery. However, scanning electron microscopy showed cilia of various lengths. The cilia did not return to normal until day 14. On day 21 and thereafter, the mucociliated epithelium was essentially normal.The infection is sequentially similar to acute mild rhinitis in humans.
耳鼻咽喉科臨床学会の論文