耳鼻咽喉科領域の神経ペプチドに関する免疫組織化学的研究-1-中耳粘膜および耳管における神経ペプチド分布

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The peptidergic innervation of the guinea pig's middle ear mucosa and eustachian tube was studied by the immunohistochemical method.Concerning the middle ear mucosa, we tested 4 kinds of peptide antibodies-SP, VIP, GRP, and APP. All of them stained well by either the FITC or PAP method. Most of these nerve fibers are found along small blood vessels, but some of them run independently. GRP is only scarcely distributed, while the other kinds are well distributed. However around the tubal tympanic oriffice, all four kinds of peptidergic nerve fibers were found in abundance.The peptidergic innervation of the eustachian tube has already been studied concerning VIP and APP. In this paper, we tried and succeeded in displaying the SP nerve fiber distribution in the eustachian tube by either the FITC or PAP method. And we found that they are well distributed near the pharyngeal oriffice. Also we were able to find them in the subepithelial region and around blood vessels, but a little a round the tubal grands.This innervation of peptidergic nerve fibers in the middle ear mucosa and eustachian tube was comparatively similar to the innervation of adrenergic and cholinergic nerve fibers.SP, VIP and GRP were not affected by the resection of the superior cervical ganglion, but it caused a reduction of the APP nerve fibers in the middle ear mucosa.As a result of this study, we can suggest that the peptidergic nerve fibers in the middle ear and eustachian tube have a vasomotor and secretory actions, and work with both adrenergic and cholinergic nerve fibers in preventing infection and in helping to remove mucous secretions from the middle ear.
耳鼻咽喉科臨床学会の論文

耳鼻咽喉科領域の神経ペプチドに関する免疫組織化学的研究-1-中耳粘膜および耳管における神経ペプチド分布

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