実験的正円窓破裂の聴覚生理学的組織学的研究

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概要

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• The initial part of the present investigation clarified the relationship between hearing impairment and the pathology of the cochlea in experimentally-induced round-window membrane (RWM) rupture. The auditory brain stem response (ABR) was employed to assess hearing of the animals. In 15 (56%) of the 27 guinea pigs, hearing loss immediately after the rupture remained within 10dB. In these animals, there was no injury of the organ of Corti, despite hemorrhage in the perilymphatic space. In 4 of the 7 animals which survived from 7 to 100 days, during which hearing loss was within 10dB immediatery after the rupture of the RWM, no further deterioration of hearing ensued, and there was no specific pathologic change in the cochlea except for hemorrhage of the perilymphatic space. The results indicated that the RWM rupture alone might not cause serious hearing impairment as long as the organ of Corti remained intact.In the latter part of the present study, comparative histological study of the healing process of the RWM ruptures was performed in 13 guinea pigs using the fascia and the perichondrium. After the RWM was totally ruptured, it was closed with the temporal fascia in 6 guinea pigs and with the perichondrium in 7. One to three months after surgery, histological specimens of the RWM were obtained. Either the temporal fascia or perichondrium seemed to function as a "supporting guide" in closure of the RWM and the healing process of the RWM rupture with these materials were essentially the same. Complete absorption of these materials usually took three months.

• 耳鼻咽喉科臨床学会の論文

著者

• 柳原 弘男

  愛媛大学医学部耳鼻咽喉科学教室

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