Normal and abnormal (cleft lip) development of the primary palate in the mouse embryo: A scanning electron microscopic study.
スポンサーリンク
概要
- 論文の詳細を見る
Little is known about the pathogenesis of cleft lip, compared with that of cleft palate, because normal developmental processes of the primary palate have not been thoroughly clarified. In this study, scanning electron microscopy was carried out on epithelial cells of the primary palates and mesenchymal cells just underlying the epithelia both in normal and abnormal (cleft lip) embryos in the 9.5-13.5 th gestation days. The latter was induced with i. p. injection of hydantoin to A/J mice. The following results were obtained.<BR>1) The epithelial changes in the normal primary palate formation, were the same as those reported previosly during the secondary palate morphogenesis, but not in cleft lip malformation. These changes in normal animals appear to be associated with the fusion of the medial and lateral nasal processes.<BR>2) Three types of epithelial cells (periderms) were recognized during the primary palate formation. Because these three types of cells might specifically appear according to differentiation of each part of the embryos, this classification may represent some information on inner developmental changes.<BR>3) In hydantoin-treated embryos, both posterior ends of medial and lateral nasal processes did not fuse, and thus mutually separated to cause partial or complete cleft lips according to degree of the breakdown of the isthmus. The main cause of these failures seems to be related to abnormalities in mesenchymal cells adjacent to the surface epithelium.
- 社団法人 日本口腔外科学会の論文
著者
関連論文
- 口腔内に発現した巨大なPyogenic Granulomaの1例
- 口腔小唾液腺由来のまれな乳頭状嚢腺腫の1例
- 顎・顔面奇形の3症例
- 抜歯後疼痛に対するSaridon-Aの効果--二重盲検法による協同研究
- 下顎に発生した骨肉腫の2例
- A case of multiple supernumerary teeth developed from the third dental laminas.
- Normal and abnormal (cleft lip) development of the primary palate in the mouse embryo: A scanning electron microscopic study.