An Electron Microscopic Study on the Extra-abdomtnal Desmoid Tumor

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An electron microscopic study has been made on an extra-abdominal desmoid tumor with several recurrence on the gastrocnemius muscle region of the right leg in a 24-year-old female. The tumor mass removed from the patient, of hard rubber-like consistency, was infant head-sized, white or yellow in colour, and the demarcation line was obscure. This tumor, histologically, presented an appearance of fibroma with a marked proliferation of the connective tissue. Electron microscopically, this tumor was composed of slender ficroblastlike cells and abundant collagen fibers. The cytoplasm of the fibroblast-like cells was filled with dilated cisternae of the roughsurfaced endopiasmic reticulum involving dense filamentous material, well-developed Golgi complex, and a great number of lysosomes. An extremely complexed shape of the tumor cell-nucleus with invagination or indentation was observed, and intranuclear inclusions surrounded by well difined double nuclear membranes were also frequently found in the nuclei. Another point of interest is that the collagen fibrils with an axial repeating structure of about 700 Å were seen in the matrix of the cell, sometimes surrounded by unit membranes. Mature collagen fibrils in the cell have been scarcely reported except in the case of sarcoma cells.
西日本整形・災害外科学会の論文