The Five Cases of Pigmented Villonodular Synovitis -Histopathology and Clinical Course-

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The five cases of pigmented villonodular synovitis are presented. These cases were two males and three females. The age range in these cases was 19 to 56 years. The knee was involved in three, the ankle one and toe one.In this paper, the histopathological findings and the clinical course were discussed.The histologic pattern is basically consist of masses foam cells, multinucleated giant cells, hemosiderin, fibroblasts with capillary proliferation. Especially, the foam cells and multinucleated giant cells were characteristic. It is suggested that these cells were originated from the mesenchymal tissue.In these cases of pigmented villonodular synovitis extirpation of the lesions is indicated as the favorable therapeutic procedure. In the course of the lesions, there is no evidence of recurrence for one to six years after extirpation in the writer's own experience.The true nature and genesis of pigmented villonodular synovitis is unclear. The idea of the tumorous condition secondary to the inflammatory response rather than neoplasia is suggested from the clinical and histopathological findings.
西日本整形・災害外科学会の論文