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Three cases of vitamin D resistant rickets were reported. All cases showed normal serum Ca level, low serum P level and greatly increased alkaline phosphatase activity, X-ray examination revealed the characteristic cupped and irregular metaphysis of the the wrist. These cases were treated with large doses of Alfarol (1α-OH-D3).Serum alkaline phosphatase was depressed by the treatment while serum Ca and P were not elevated. The bone changes were disappeared by the treatment in all cases. The leg deformity was markedly improved after 2-3 years treatment but one month interruption of the treatment was followed by a relaps of the bone changes and increased leg deformity. It was suspected that the serum Mg level has to be examined when a large doses of 1α-OH-D3 is given.
- 西日本整形・災害外科学会の論文
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