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We have examined the efficacy and safety of Auranofin (AF) clinically in 13 patients with Rheumatoid arthritis.Subjects were the female out-patients of our clinic for RA, their ages ranging from 35 to 72. Six and 7 cases were diagnosed as Classical and Definite RA, respectively.AF was administered at 6mg/day continuously. The mean dosing period was 27 weeks (max. 42 weeks and min. 4 weeks). Of all 13 cases, 2 cases were withdrawn from the study and 8 patients showed "effective". Major improvements were observed in Lansbury index, morning stiffness and ESR. Total 13 side-effects were reported, 6 of rash or itching, 2 of gastric disorder, each one of stomatitis, edema and nitritoid-reactionlike symptom. The present study suggests that AF is easy to administer clinically because it can be administered to the patients where injection is difficult due to adverse reactions or to the patients who have some problems to visit the hospital. Also the gold dose can be adjusted easily by AF.
- 西日本整形・災害外科学会の論文
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