Serum levels of Cefamandole in Drainage tube

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Cefamandole (CMD) is a new semisynthetic derivative of cephalosporin. The serum levels of CMD were measured with the bioassay method in the venous blood and in the drainage tube after 12 hip operations. CMD was administered by the injection at a dose of 2 grams.The mean peak serum level in venous blood was 101.52μg/ml at 30 minutes after injection, and thereafter the mean level was decreased rapidly to 45.59μg/ml at one hour and 17.2μg/ml at 2 hours. But the mean peak serum level in drainage tube was 41.56μg/ml at one hour and 41.50μg/ml at 2 hours, and thereafter the mean level was decreased gradually to 33.25μg/ml at 3 hours and 24.5μg/ml at 4 hours. The time required for an operation and bleeding during operations showed no influence on the serum levels of CMD. But the aged patients showed higher serum level of CMD in venous blood.