An experimental study on vascularized bone allograft transplantation. First report of immunological and hematological study.:First Report of Immunological and Hematological Study

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An experimental study on vascularized bone allograft transplantation using immunosuppressors was reported.The purpose of this paper is to discuss outbreak of the side effects of immunosuppressors and graft versus host reactions in vascularized bone allograft transplantation using immunosuppressors. And we also purposed studying correlation of spontaneous leukocyte blastogenesis with vascularized bone allograft rejection as a clinical marker to detect the rejection.Adult mongrel dogs were used in this study.Cyclosporin A (20mg/kg/day) or FK506 (1 or 0.32mg/kg/day) was used as an immunosuppression of allograft during the first three postoperative months.Evaluation of side effects of immunosuppressors, graft versus host reaction and rejection were obtained mainly with hematologically and clinically.Cyclosporin A successfully suppressed graft rejection in vascularized bone allograft transplantation. And it had no bad effect on general condition, kidney function, hematopoietic function although high blood lebel of cyclosporin A. But poor results were got with high dose of FK506 because of its side effect.There was no findings of graft versus host reaction under cyclosporin-A and FK506.Spontaneous leucocyte blastgenesis might be a useful clinical marker to detect the rejection.
西日本整形・災害外科学会の論文