Clinical evaluation for predicting the response of osteosarcoma to preoperative treatment.

概要

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The response of osteosarcoma to preoperative treatment, which was classified by the degree of histologic tumor necrosis as good (4 cases), poor (5 cases) and fair (one case), was evaluated in 10 cases by using the value of serum alkaline phosphatase (sALP), conventional radiography, 99mTc-MDP scintigraphy, computed tomography (CT) and angiography before and after the treatment.All of the good responding cases showed the findings of a decreased uptake in 99mTc-MDP scintigraphy. A shrinkage of soft tissue mass on CT was seen in only 2 good responding cases. Angiography in 3 good and one fair cases revealed a decrease in tumor vascularity. The change of sALP value and radiographic findings were not correlated with the degree of histologic tumor necrosis.Therefore, 99mTc-MDF scintigraphy, CT and angiography would be of use for predicting the response of osteosarcoma to preoperative treatment.
西日本整形・災害外科学会の論文