Evaluation of Chemotherapeutic Efficacy by Magnetic Resonance Imaging.

概要

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We reviewed magnetic resonance images (MRI) of eight patients with osteosarcoma and one patient with Ewing's sarcoma treated with preoperative chemotherapy. MRI was performed with a Signa 1.5-Tesla superconducting magnet. Comparisons were made between the percentage of tumor necrosis calculated by histologic maps of the surgical specimens and the following four items: first, changes of signal-intensity inside the tumors, second, the reduction of reactive zone surrounding the tumors, which shows a high intensity on T2-weighted images, third, the increase of clearness around the tumors, which shows a low intensity on T1 and T2 images and finally, the reduction in size of the extraosseous components of the tumors. A significant correlation was observed between the reduction and the percentage of tumor necrosis. The reduction in size of the extraosseous components of tumors may be useful in evaluating chemotherapeutic efficacy.
西日本整形・災害外科学会の論文