Bone Turn-over in Paget's Disease.

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Bone turn-over of Paget's disease was examined by biochemical and histomorphometric analysis in one female and two male patients, aged 72, 48 and 68, respectively.All patients had polyostotic lesions involving the tibia, femur, pelvis, spine and skull. Elevations in serum alkaline phosphatase reflecting bone formation were demonstrated in all patients, and a high level of serum BGP was found in one patient. Increases in the urinary excretion of calcium and hydroxyproline were also noted, as a result of excessive bone resorption.Histomorphometric data indicated that bone resorption and subsequent bone formation were highly excessive in Pagetic bone. Approximately 36% of bone surfaces were eroded, and 21% were osteoid in the 68-year-old male. In this specimen, the so-called mosaic pattern and woven bone pattern were also seen, reflecting rapid bone turn-over.Calcitonin and etidronate disodium, or EHDP, were administered to each patient. EHDP was associated with a decrease in serum alkaline phosphatase levels, and urinary excretion of calcium and hydroxyproline, much as was observed with calcitonin.
西日本整形・災害外科学会の論文