Expression and Distribution of Transforming Growth Factor-.BETA. and Decorin during Fracture Healing.

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To study the interactions between TGF-β and decorin, we experimentally induced femoral fractures in rats and immunohistologically examined changes in the distribution of TGF-β and Decorin in the femur 3, 7, 14 days after fracture. In areas where endochondral ossification occurred, Decorin was detected during differentiation of mesenchymal cells into proliferating chondrocytes, but no TGF-β was observed during the same period. After the chondrocytes had hypertrophied, Decorin was no longer observed, while the matrix around the hypertrophic chondrocytes was positively stained for TGF-β. The disappearance of Decorin, almost simultaneously accompained by the appearance of the active type TGF-β, suggests that Decorin regulates the action of TGF-β.
西日本整形・災害外科学会の論文