Experimental Instradiscal Drug Injection: Histological Studies and Measurement of Intradiscal Pressure.:Histological Studies and Measurement of Intradiscal Pressure

概要

論文の詳細を見る
We investigated the pathological changes and alterations in intradiscal pressure after an experimental intradiscal injection in the mature rabbit. Thirty intervertebral discs in 6 rabbits were used as controls, and normal pressures were measured. Chymopapain, 10% sodium chloride, or betamethasone were injected separately into 5 intervertebral discs of 9 rabbits. Rabbits were sacrificed at 1 week, 4 weeks, and at 12 weeks after the intradiscal drug injection. The intradiscal pressure changed depending on the degree of disc degeneration and if there was any regeneration. The chymopapain-injected intradiscal pressure decreased significantly at 4 weeks compared with the pressure at 1 week and at 12 weeks (p<0.05, p<0.01 respectively). The intradiscal pressure of the 10% sodium chloride-injected discs decreased at 4 weeks, but by 12 weeks the pressure had recovered to the same level as fourd in the cotrols. Necrotic nucleus pulposus was seen histopathologically at 1 week after chymopapain injection, and at 1 week after the 10% sodium chloride injection. At 12 weeks, there intervertebral discs had regenerated with chondrocytes different from in the normal nucleus pulposus.The pressure of the betamethasone-injected discs was unchanged throughout the 12 weeks with only slight histological changes.
西日本整形・災害外科学会の論文