Surgical results of thymoma cases with reference to preoperative diagnoses, preoperative therapies, and prognostic factors.

概要

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The prognoses of 39 consecutive thymoma patients treated by surgery from 1977 to 1998 were retrospectively analyzed, with special reference to their preoperative diagnoses, preoperative therapies, and prognostic factors. A pathological diagnosis could be obtained in 26 of 32 patients (81.3%) before surgery by a percutaneous needle biopsy or aspiration cytological examination. Preoperative chemotherapy or irradiation was administered to 10 patients with an unresectable invasive lesion by diagnostic imaging, and the response rate was 80%. There were 13 patients with Masaoka's stage I, 7 with stage II, 15 with stage III, and 4 with stage IVa. The 10-year survival rate was 80% overall, 100% for stage I and II, and 72.7% for stage III patients. The 10-year survival rate for those patients who underwent complete and incomplete resections was 90.7% and 33.3%, respectively (p<0.0001) The 10-year probability of survival for those patients treated by preoperative therapy was 66.7%.Stage (p=0.0059) and the completeness of resection (p=0.0014) were the prognostic factors by univariate analysis. These results suggest that preoperative therapy for an invasive thymoma is effective and multimodality therapy with surgery might improve the prognosis. Masaoka's stage and completeness of resection were the prognostic factors in thymoma cases treated by surgery.
特定非営利活動法人日本呼吸器外科学会の論文