A Clinical Study on Serum Alkaline Phosphatase in Hepatic Diseases, mainly Hepatitis and Cirrhosis

概要

論文の詳細を見る
Range and ratio of abnormality in serum alkaline phosphatase activity in various liver diseases were reported and discussed at the viewpoint of pathophysiology.<BR>The activity was found to increase mostly in acute stage of infectious and also serum hepatitis. It was, however, almost within normal limit in subchronic including its persistent type, chronic and precirrhotic stage. Activity of serum glutamicoxaloacetic transaminase (SGOT) showed similar pattern of changes as alkaline phosphatasein above mentioned cases which had higher phosphatase activity at the onset.<BR>As the disease progressed the phosphatase activity was apt to increase when SGOT was remarkably high at first.<BR>In cholestatic type, it seems to be conspicuous feature of this type that alkaline phosphatase activity increased even when SGOT activity was under 100 or sometimes normal. When the isease started with positive serum colloidal reactions, serum bilirubin and alkaline phosphatase showed minor increase in their level. On the other hand SGOT was found to be increased rather continuously in these cases and in cholestatic type, serum alkaline phosphatase showed the tendency to return to normal even when SGOT was over 100 U.<BR>It might be considered that abnormality in mesenchymal system would diminish changes of serum alkaline phosphatase and serum bilirubin.
財団法人日本消化器病学会の論文