On the Changes of Bile Constituents in Cases of Cystic Duct Occlusion by an Impacted Calculus

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The main bile constituents, cholesterol, phospholipids and bile acids were determined inbile both from the gallbladder and the common duct in cases of cystic duct occlusion by animpacted calculus. The concentration of these substances were markedly decreased in bladderbile, the degree of which corresponding with the appearance of the bile and the structuralchanges of the gallbladder wall. The changes were not proportional, but, phospholipids andbile acids decreased more than cholesterol and made the condition of cholesterol solubilityworse. In common duct bile, all of cholesterol, phospholipids and bile acids were increasedstatistically significantly, compared to cholecystolithiasis without cystic duct occlusion. Thedefection of concentrating activity of the gallbladder could be substituted by liver or bile ductto some extent.
財団法人日本消化器病学会の論文