Experimental studies on the mechanism of the pancreatic exocrine secretion:Part II. Na+, K+, and Cl- Transport Induced by Secretin in the Perfused Dog Pancreas

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In order to clarify the mechanism of the pancreatic exocrine secretion, transport processes of Na+, K+, and CI- were studied on the perfused dog pancreas. First, the relation between the flow rate of perfusion and perfusion pressure was studied. Judging from the result of measured values of perfusion flow rate and perfusion pressure, a temporary decrease of perfusion pressure was observed after slimulation of secretin. The change was considered to be due to a vascular dilatation. Second, in an attempt to analyse Na+, K+, and CI- transport induced by secretin, the perfusion with normal Ringer solution was carried out, and the ionic concentration of arterial and venous perfusates and pancreatic juice was measured. The temporary efflux of K+ from the cell to the perfusate and the prominent influx of Na+ and CI- from the perfusate to the cell were observed. These ionic changes occured faster than the secretion of pancreatic juice. In the perfusion with isotonic containing low Na (as replaced with sucrose) Ringer solution, Na+ in the pancreatic juice showed higher concentration than in the perfusate, though they were isosmolal. In fact, as described above, it was verified that an active transport of Na+ exists in the secretory process of pancreas.
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