Studies on Carbohydrate Metabolism in Experimental Fatty Liver
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Carbohydrate metabolism in liver was studied on Hoffbauer's Stages I to IIIA of fatty liver induced by choline-deficient diet with special reference to the utilization of 14C-u-glucose and 14C-u-xylitol and the variation of some enzymic activities and intermediates related to carbohydrate metabolism.<BR>The histological patterns of liver in choline deficient group developed in a similar manner to those shown in Hoffbauer's classification. Week after week triglyceride increased and phospholipid decreased as far as the changes of liver lipids are concerned.<BR>The isotopic experiments revealed the fact that development of choline -deficient fatty liver was accompanied by a gradual disturbance of utilization of glucose and xylitol for glycogen formation and energy source. Glucokinase activitywas obviously reduced even at the initial stage of fatty liver, indicating an insufficient phosphorylation of glucose. Glycogenesis decreased week after week.<BR>The variation of G-6-PDH activity suggested that pentose phosphate cycle was kept at the normal level at the initial stage, but it was gradually disturbed along with fatty liver development. The activities of GAPDH (S) and pyruvate kinasewere elevated and the amount of liver pyruvate was increased, which reflects that the metabolic pathway from triose to pyruvate might be in a rather promoted state at Stage I. Lactate amount, however, remained unchanged and LDH activity was slightly raised on the 5th week.<BR>The variation of the activities of acetyl-CoA carboxylase and NADP-ICD (S) indicated that fatty acid synthesis was significantly promoted at the initial stage of fatty liver and that glucose and xylitolmight be utilized for fatty acid synthesis via acetyl-CoA rather than for lactate formation through reduction of pyruvate. Energy metabolism in mitochondria, as seen from the variation of NADP-ICD (Mt) and GAPDH (Mt) activities, might rather be in a promoted state at the initial stage of fatty liver, but be graduallyinjured along with fatty liver development. Gluconeogenesis, as seen from the variation of G-6-Pase and FDPase activities, was also be in a rather promoted state at the initial stage, and then gradually disturbed along with fatty liver development.<BR>These results led to the conclusion that a clear-cut difference in the pattern of carbohydrate metabolism could be observed between Stage I and Stages II & IIIA.
- 財団法人 日本消化器病学会の論文
財団法人 日本消化器病学会 | 論文
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