Tissue Fibrinolytic Activity in Digestive Tract:I. Stomach Ulcer
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概要
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It has long been known that the increased fibrinolytic activity in man is accompanied with gastrointestinal ulceration or bleeding, and many investigations have been done concerning to the fibrinolytic activity of blood in patients with gastric and duodenal ulcer. But, fibrinolysis in blood is easily affected by emotional or surgical stress, or by various physical conditions, estimation of fibrinolysis in tissues seems to give us more accurate informations. Immune reaction in the gastric mucosa has been reported by Kondo (1969) by the technique called Passive Mucosal Anaphylaxis (PMA), and also by producing experimental ulcer using immune complex. In experimental dog stomach ulcer produced by immune complex, fibrinolytic activity in the mucosa was localized around the ulcer, and increased to maximum between 2 to 12hours after the injection of immune complex, while the specimen obtained by surgical operation from human stomach ulcer did not have the tendency to increase or localize. This discrepany was explained due to difference of the phase of ulcer, since the biopsied mucosa from patients with short history of ulcer showed relatively high fibrinolytic activity.<BR>Furthermore, fibrinogen in the mucosa around the human stomach ulcer determined by single radial immunodiffusion was decreased compared to that in the distant area, suggesting the fibrinogen was converted to fibrin at the affected area, and was used up by the interaction with increased fibrinolytic activity.
- 財団法人 日本消化器病学会の論文
財団法人 日本消化器病学会 | 論文
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