:Part II Changes of Plasma Glucagon and Insulin Level in Response to Arginine Treatment in Rats with Liver Disorders Induced by CCL<SUB>4</SUB>

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• Pancreatic endocrine function was investigated in rats with liver disorders induced by CCl<SUB>4</SUB>treatment.<BR>The results obtained were as follows:<BR>1. Basic plasma glucagon level in rats with short-term CC14 treatment showed no significant difference compared with that in the control group, however, the level in rats with chronic liver disorder induced by CCL<SUB>4</SUB> treatment was significantly higher than that in the control.<BR>Basic plasma insulin level in rats with acute liver disorder induced by CCl<SUB>4</SUB> treatment was significantly higher than that in the control, but no difference was observed between the plasma insulin level in rats with chronic liver disorder induced by CCl<SUB>4</SUB> and that in the control.<BR>2. There was no significant difference between the plasma glucagon level in response to arginine administration in rats with acute liver disorder induced by CCl<SUB>4</SUB> treatment and that in the control, however, significantly higher responsiveness was observed in rats with chronic liver disorder by CCl<SUB>4</SUB> treatment compared with that in the control.<BR>On the other hand, a significantly hyper-response of plasma insulin increase to arginine administration was observed in rats with acute liver damage induced by CCl<SUB>4</SUB> treatment and a decrease was observed in an inverse manner in rats with chronic liver damage.<BR>3. These changes were more pronounced when the levels of plasma insulin and glucagon were estimated by molar ratio (I/G).<BR>In conclusion, it was conjectured that the abnormalities of pancreatic endocrine function observed in rats subjected to CCl<SUB>4</SUB> treatment were closely related to the pathophysiological conditions of impaired liver cells.

• 財団法人 日本消化器病学会の論文

財団法人 日本消化器病学会 | 論文

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